• Monkey in the Colombian Amazon. Monkeys are natural sentinels: their death can provide early warning of the spread of the yellow fever virus, allowing immediate control measures to be implemented.
    / WHO / Karen González Abril
    Credit

Yellow Fever: How three monkey deaths sparked a critical health alert in Colombia

July 2025


When three monkeys (a howler, a white-faced monkey, and a spider monkey) were found dead in a forested area of Colombia’s Putumayo department, what might have previously gone unnoticed became an early warning sign that triggered a swift, coordinated response to contain a yellow fever outbreak. This time, the difference was knowledge.

"Thanks to the training we received on proper sample collection in primates, we were able to detect a yellow fever outbreak after discovering three dead monkeys at the same time,” said Wilder Pérez, from the Putumayo Health Secretariat’s Vector-Borne and Zoonotic Disease Program. “Without that knowledge, the animals might have been buried without analysis — and we would have missed a critical opportunity to act.”

“The training allowed us to detect an outbreak in time,” said Wilder Pérez, of the Putumayo Health Secretariat, applying what he learned in the first /WHO workshop on early warning signs.
Credit: /WHO/Karen González Abril - “The training allowed us to detect an outbreak in time,” said Wilder Pérez, of the Putumayo Health Secretariat, applying what he learned in the first /WHO workshop on early warning signs.

Wilder had participated several months earlier in a regional workshop on epizootic and vector surveillance, organized with technical support from the () under the PROTECT initiative, funded by the Pandemic Fund. During the training, health teams were taught how to safely collect samples from wildlife, conduct vector surveillance, and coordinate across sectors.

The workshop, held in Tolima—another key department in Colombia’s current yellow fever response—proved crucial for enabling the Putumayo team to act swiftly when the first signs of the virus emerged.

En Mocoa (Putumayo), equipos de salud de más de diez territorios participaron en el Segundo Taller de Vigilancia Epizoótica y Vectorial, con el fin de fortalecer la detección y respuesta oportuna frente a la fiebre amarilla.
/WHO/Karen González Abril - In Mocoa (Putumayo), health teams from more than ten territories participated in the Second Workshop on Epizootic and Vector Surveillance, with the aim of strengthening early detection and response to yellow fever.

The training paid off. Once the dead monkeys were reported, immediate measures were taken — vaccinating environmental workers, conducting entomological studies, and analyzing the affected area. As a result, the surveillance system not only confirmed the presence of the virus, but also prevented its spread to nearby urban areas.

Tolima, for its part, is facing the most severe outbreak recorded in the country outside the Amazon region. In this department alone, from late 2024 through June 28, 2025, 95 human cases of yellow fever have been confirmed, including 35 deaths.

Los participantes practicaron la toma de muestras en fauna silvestre bajo estrictos protocolos de bioseguridad, incluyendo un ejercicio con un primate fallecido en el Centro de Educación Ambiental de Mocoa.
Credit: /WHO/Karen González Abril - Participants practiced taking samples from wildlife under strict biosafety protocols, including an exercise with a deceased primate at the Mocoa Environmental Education Center.


An Expanding Surveillance System

From 2024 through epidemiological week 26 of 2025 (ending June 28), Colombia has confirmed 114 human cases of yellow fever, including 49 deaths, with a case fatality rate of 42.9%. The most affected departments have been Tolima, Putumayo, Nariño, Caquetá, and Meta. In parallel, at least 56 epizootics (deaths of non-human primates) due to yellow fever have also been confirmed in the country.

All confirmed cases are associated with the sylvatic transmission cycle — involving mosquitoes in forested areas that bite infected non-human primates and then humans. This highlights the importance of maintaining high vaccination coverage in rural communities and strengthening wildlife surveillance through a One Health approach that integrates human, animal, and environmental health.

Tolima’s experience — where no human cases had been reported in over a century — has brought valuable lessons to Colombia’s national health system. As a result, epizootic surveillance mechanisms have been strengthened in other regions, improving integrated responses across health and environmental sectors.

“These experiences help share knowledge between regions, standardize protocols, and support more timely interventions,” said Mauricio Vera of Colombia’s Ministry of Health and Social Protection.

Integrated surveillance — combining monkey and mosquito monitoring — was a key focus of the Second Workshop on Epizootic and Vector Surveillance, held in May 2025 in Mocoa, Putumayo. Participants included professionals from Colombia’s Ministry of Health, National Institute of Health, Ministry of Environment and Sustainable Development, National Parks, /WHO, the Pan American Center for Foot-and-Mouth Disease and Veterinary Public Health (PANAFTOSA), and Brazil’s Ministry of Health. They shared tools and experiences for early detection and outbreak control.

A Regional Threat Beyond Colombia

The Tolima outbreak is not an isolated event. So far in 2025, five countries in the Americas — Bolivia, Brazil, Colombia, Ecuador, and Peru — have reported confirmed yellow fever cases, with an average fatality rate of 41%. Health authorities are particularly concerned by cases emerging outside traditional endemic zones like the Amazon region.

The virus’s spread to Tolima, Colombia, and São Paulo, Brazil, signals changing transmission patterns, underscoring the need for expanded surveillance in new areas. In response, /WHO is urging countries to maintain active surveillance, vaccinate at-risk populations, and ensure rapid responses to early warning signs — such as unexplained monkey deaths.

Credit: /WHO/Karen González Abril - During the workshop, practical exercises were carried out on vector surveillance, which is key to identifying and controlling diseases such as yellow fever by monitoring mosquitoes and their habitat.

Ecosystem Health: Beyond Humans

“Human health depends on ecosystem health,” said Mayra Alejandra Vargas of Colombia’s Ministry of Environment and Sustainable Development. “Primates, who are currently the most affected, are closely connected to us. What puts them at risk, puts us at risk too,” she emphasized.

The experiences in Tolima and Putumayo show that the One Health approach — linking human, animal, and environmental health — is not just theory. In high-biodiversity settings, active jungle surveillance can mean the difference between containing an outbreak or facing a major health emergency.

 / WHO / Karen González Abril - Mocoa (Putumayo), Second Workshop on Epizootic and Vector Surveillance.
Credit: / WHO / Karen González Abril - Mocoa (Putumayo), Second Workshop on Epizootic and Vector Surveillance.

Epidemiological Alert Yellow fever in the Americas Region - 31 May 2025