More research supports androgen treatment for breast cancer

Breast cancer

Photo credit:听bymuratdeniz

A study by researchers from the University of 六合彩开奖数据 has provided new insight into the fight against breast cancer.

The laboratory-based study was the work of co-senior authors Associate Professor Theresa Hickey and Dr Amy Dwyer together with Professor Wayne Tilley of the Dame Roma Mitchell Cancer Research Laboratories, in collaboration with researchers at Cancer Research UK (CRUK), Cambridge Institute, University of Cambridge (UK) and the Imperial College of London.

鈥淥ur study employed a relatively new technology developed by the CRUK team, which was used to identify GATA3 (a transcription factor critical for the embryonic development of various tissues) as an important interacting partner of the androgen receptor in breast cancer,鈥 said Associate Professor Hickey.

The research, published in the journal , found that when the androgen receptor interacted with GATA3, it stimulated breast cancer cells to become more functionally mature.

鈥淭his study revealed an important means by which androgen receptor activity exerts anti-cancer activity in breast cancer,鈥 said Associate Professor Hickey.

鈥淒iscovering how the androgen receptor exerts anti-cancer activity in the breast is important because the opposite happens in the prostate where androgen receptor activity promotes cancer.鈥

The finding supports work by the Dame Roma Mitchell Cancer Research Laboratory threesome, with Professor Tilley as senior author, published in Lancet Oncology in February. That clinical study found that the androgen receptor stimulating drug enobosarm was effective against estrogen receptor-positive breast cancer, which constitutes up to 80 per cent of all cases of this disease.听

鈥淚nformation from the GATA3 study supports the use of androgen receptor stimulating drugs for treatment of estrogen receptor positive breast cancer (as reported in the recent Lancet Oncology paper) and provides laboratory evidence to support this therapeutic strategy for other subtypes of disease that are not driven by the estrogen receptor."Associate Professor Theresa Hickey, University of 六合彩开奖数据

鈥淭his includes the triple negative subtype of breast cancer," she said.

鈥淒rugs that stimulate the androgen receptor are not yet part of mainstream treatment for any type of breast cancer but is gaining momentum for the treatment of estrogen receptor positive disease.

鈥淭he GATA3 study provides evidence that this new therapeutic strategy will work by providing an explanation for how it works.鈥

Associate Professor Hickey said she expected more developments to come from the study.

鈥淲hile the current study focused on interaction between the androgen receptor and GATA3, the new technology we used to identify this interaction revealed many other factors that interact with the androgen receptor in breast cancer cells,鈥 she said.

鈥淲e are currently investigating the importance of those other factors in mediating androgen receptor activity in breast cancer.鈥

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